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- Quantitative Analysis of Blood Hormones
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- Purpose
- - Measurement of changes in various blood markers and hormones
- Evaluation Items
- - Insulin
- - C-peptide
- - Glucagon
- - Leptin
- - GLP-1
- - Cortisol
- - Cortisone
- - Hemoglobin A1c
- Method
- - RIA/ELISA
- Blood Lipid Profiles
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- Purpose
- - Analysis of blood lipid metabolites
- Evaluation Items
- - Kidney function - BUN(Blood urea nitrogen), Creatinine, Uric acid
- - Liver function - Glucose, Albumin, ALT(Alanine transferase), AST(Aspatate aminotransferase),
- - ALP(Alkaline phosphatase), Total bilirubin, Direct bilirubin, Indirect bilirubin, Total protein
- - Lipid function - Cholesterol, Triglycerides, HDL-cholesterol, LDL-cholesterol
- - Free fatty acid
- Method
- - Measurement of plasma lipid profiles
- Characteristics
- - Conduct 17 examinations at a time.
- Lipoprotein Fractionation
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- Purpose
- - Measure the hypolipidemic effects of drug candidates on plasma triglycerides and cholesterol
- Evaluation Items
- - VLDL, LDL, HDL Fractionation
- - Quantitative analysis of cholesterol/ triglycerides in each lipoprotein
- Method
- - Use FPLC and Superose 6-column chromatography and quantitatively analyze cholesterol in blood lipoproteins and lipoprotein content changes in triglycerides in the animal model
- Tissue Lipid Metabolite Analysis (Lipidomics)
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- Purpose
- - Analysis of glucose / lipid metabolites and enzyme activity in the tissues and plasma
- Evaluation Items
- - 5 types of diacylglycerol
- - 7 types of cerimide
- - 3 types of dihydroceramide
- - 4 types of glycosylceramide
- - 3 types of sphingomyelin
- - sphingosine, sphinganine, sphingosine 1-phosphate
- - 9 types of fatty acyl CoA
- - 20 types of free fatty acids
- Method
- - Analysis of lipid metabolites in tissues and blood by using of LC/MS/MS ABI 4000-Q Trap and GC/MS to find correlation of accumulated lipotoxic metabolites and disease development.
